/Ca Exchangers and Mitochondria in Ca Clearance at the Calyx of Held
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چکیده
Myoung-Hwan Kim,1 Natalya Korogod,2 Ralf Schneggenburger,2 Won-Kyung Ho,1 and Suk-Ho Lee1 1National Research Laboratory for Cell Physiology, Department of Physiology, Seoul National University College of Medicine, Chongno-Ku, Seoul 110-799, Korea, and 2Arbeitsgruppe Synaptische Dynamik und Modulation and Abteilung Membranbiophysik, Max-Planck-Institut für Biophysikalische Chemie, D-37077 Göttingen, Germany
منابع مشابه
mitochondria-dependent post-tetanic potentiation at the rat calyx of Held
12 Developmental changes in Ca 2+ clearance and short-term plasticity 13 14 15 Abstract 26 27 The sensitivity of post-tetanic potentiation (PTP) to high frequency stimulation (HFS) steeply decays during 28 the first two postnatal weeks. We investigated the underlying mechanisms for the developmental change of PTP 29 induced by HFS (100 Hz, 2 sec) at postnatal days 4-6 and 9-11 at the rat calyx ...
متن کاملDevelopmental upregulation of presynaptic NCKX underlies the decrease of mitochondria-dependent posttetanic potentiation at the rat calyx of Held synapse.
The sensitivity of posttetanic potentiation (PTP) to high-frequency stimulation (HFS) steeply decays during the first 2 postnatal weeks. We investigated the underlying mechanisms for the developmental change of PTP induced by HFS (100 Hz, 2 s) at postnatal days 4-6 and 9-11 at the rat calyx of Held synapse. Low-concentration tetraphenylphosphonium (2 μM), an inhibitor of mitochondrial Na(+)/Ca(...
متن کاملPresynaptic release probability and readily releasable pool size are regulated by two independent mechanisms during posttetanic potentiation at the calyx of Held synapse.
At the immature calyx of Held, the fast decay phase of a Ca(2+) transient induced by tetanic stimulation (TS) was followed by a period of elevated [Ca(2+)](i) for tens of seconds, referred to as posttetanic residual calcium (Ca(res)). We investigated the source of Ca(res) and its contribution to posttetanic potentiation (PTP). After TS (100 Hz for 4 s), posttetanic Ca(res) at the calyx of Held ...
متن کاملRIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse.
The localization and density of voltage-gated Ca(2+) channels at active zones are essential for the amount and kinetics of transmitter release at synapses. RIM proteins are scaffolding proteins at the active zone that bind to several other presynaptic proteins, including voltage-gated Ca(2+) channel α-subunits. The long isoforms of RIM proteins, which contain NH2-terminal Rab3- and Munc13-inter...
متن کاملcAMP Modulates Intracellular Ca Sensitivity of Fast-Releasing Synaptic Vesicles at the Calyx of Held Synapse
Yao L, Sakaba T. cAMP modulates intracellular Ca sensitivity of fast-releasing synaptic vesicles at the calyx of Held synapse. J Neurophysiol 104: 3250–3260, 2010. First published September 22, 2010; doi:10.1152/jn.00685.2010. cAMP potentiates neurotransmitter release from the presynaptic terminal in many CNS synapses, but the underlying mechanisms remain unclear. Here we addressed this issue q...
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تاریخ انتشار 2005